Random Number Generator

[Natalie]

A topic for anyone who needs random numbers for projects or decision making. Each day I will provide a randomly generated number for discussion and personal use. Please reach out if you're interested in using this service for commercial applications.

Today's number is 7,766.

[Natalie]

Today's number is 411,226.

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[Natalie]

Today's number is -24054794.

Did you know? The inverse of this number is positive 24054794, which corresponds to the Current Science Association's Use of Heavy Water in Organic Chemistry. The full text has been included below as a complimentary bonus.

USE OF HEAVY WATER IN ORGANIC CHEMISTRY


I N the 01 game synthesis section. Division of Pure Chemistry, National Research Council, Canada, the following organic compounds labelled with deuterium have been synthesized for use in chemical kinetics, photochemistry and spectroscopy

(1) Decomposition of the carbide MgoCj with deuterium oxide gives an excellent yield of propyne-d, CDjC = CD Several other compounds can be prepared from this material. For instance, chlorination gives 1, 1, 2, 2-tetrachloropropane-d^, (CDjCCInCDCH) from which, in turn, 1, 1, 2-trichloropropene-dj oi els- and trmis-1, 2-dichloropropane-dj can be prepared.

(2) Addition of deuterium bromide to i double or triple bond is another simple method of introducing deuteiium into organic compounds Thus acetylene-dj gives a quantitative yield of 1, 2-dibromoethane-d, Alternatively, deuterium bromide may be reacted with ordinary acetylene to give 1, 2-dibromoethane-1, 2-d_> It has been possible to transform both of these compounds into others, eg, ethylene-d 4 , ethyl-d- bromide, ethylene-d, oxide, etc.

(3) Deuteration of organic compounds can also be effected by exchange Such reactions are catalyzed by finely divided metals such as nickel 01 platinum For example, benzene is easily deuterated to benzene-d, by repeated exchange with deuteiium oxide in the presence of platinum black Exchange reactions may also be catalyzed by acids or bases Trichloroethylene readily exchanges its hydrogen foi deuterium when heated with deuterium oxide containing a weak base An example of in acid-catalyzed reaction is the conversion of malonic acid to malomc-do acid-d,, namely, CD^(CO_.D),,

(4) Sometimes it is more expedient to prepare a compound bj reacting a suitable starting material with deuteiium oxide and then enriching the product by exchange For example, about 20 exchanges are required to convert acetone to acetone-d,, Considerable time is saved by just preparmg deuterated acetone (about 90%) from deuteroacetj lene and then enriching it by exchange noth heavy water

The greatest difficulties are encountered m the synthesis of compounds labelled with deuterium in a specific position. A discerning choice of starting material must often be made For instance, when it recently became necessary to prepare butene-1-4, 4, 4-d4, CD-jCHnCH = CHn, the problem was solved bj reacting the hahde' C Cl , CH_ CHBr CH_.C1 with zinc and acetic acid-d In another case, acetaldehyde labelled in the formjl group was prepared by applying Nef leaction to the deuterated nitroethane, CH^CD^NO,. The foimation of the acetaldehyde-d, disproved a mechanism posed for the Nef reaction in 1950 These synthetic methods are being extended m several directions (N RC Res News, Vol 8, No 2)